Rabies-Tajh+and+DaVonte

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==History == Rabies are a viral infection which were discovered thousands of years ago. Rabies began to take effect in 3000 BC. The first record of rabies were discovered in the Codex of Eshnunna which is an ancient text. This text describes the Rabies as being deadly. Which is no different from what they are now. In the 1584 century rabies were being researched and observed by [|Girolamo Fracastoro] .He described the viral infection to be fatal towards both animals and humans. He’d later say that it’s an incurable disease. However he was proven wrong 350 years later by Louis Pasteur. Louis Pasteur was French chemist and biologist born in the city of France. While finishing the work of scientist Girolamo Fracastoro, Louis had soon made a discovery. While studying rabies, Louis had decided to extract a rabid cell from a dog, he decided to produce a less weaker form of the rabid. That cell was used to assist Louis create the vaccine for rabbies. On July 6, 1885 Louis Pasteur had decided to use his new vaccine in order to save Joseph Meister whom was bitten by a rabid dog. Louis’s treatment lasted for ten days which brought Joseph to a full recovery.  [|On March 16th 2009], there was an outbreak of Rabies which killed 93 children. This rabid epidemic took place in the city of Angola. The main cause of the rabie outbreak was from the dogs.The dogs brought from different countries to Angola were tested positive for rabbies but were set loose in the streets of Angola. Angola is a city where dogs are honored. Which was why many people began to get effected by the rabies. The rabies are killing so many children in the Eastern countries because Angola is one of the poorest cities. In order for a child to get treated of rabie cost $50.Which is hard for a family to gather.

Below are Rabies statistic for Africa and Asia

Symptoms
Symptoms of rabies are shown approximately 20-60 days after exposure. However there are two different types of rabies furious rabies and dumb rabies. **Furious Rabies:** Furious rabies are found within animals. For example dogs when dogs are encountered by furious rabies, they turn more aggressive. They began to foam at the mouth and become more hyperactive to their surroundings. Dumb Rabies are very similar to Furious rabies. However dumb rabies doesn’t make people hyperactive. It just slowly paralyzes the user. Symptoms of Rabies are flu-like symptoms. Since humans and animals can be effected by rabies, here are both symptoms: -High Fever  -Itching -Difficulty Swallowing -Head-Aches -Sore Throat -Abdominal Pain -Hydrophobia ( Fear of water)
 * Dumb Rabies:**
 * //Symptoms of Humans//**

**//Symptoms of Animals //** -Sudden Aggression -Drooling -Foaming at the mouth -Chewing on objects -No fear shown towards wild animals  -Hydrophobia ( Fear of water)


==Transmission of Rabies ==  Rabies are transmitted through mammals. They are transmitted by the fluid or saliva of the infected mammal is in contact with another persons mucous membrane. Which includes eyes, nose or mouth. Rabies are most common to live in saliva so if a human or animal is bit by another human or animal with rabies, then that mammal is then exposed to rabies. Rabies are also transferred if fluid from an infected mammals body touches broken skin of a non-infected mammal. Once the virus is in the body, the rabies makes its way to the brain by following the peripheral nerve. Rabies can be passed on from human to human. This can be done, by a human infected with rabies transferring liquids form his or her body to another human. For example sharing foods or towels. When sharing foods, saliva is transferred into both mouths which means the infected saliva is now in the clean saliva. This virus infect every organism in the body which will soon lead to death of the carrier.

==**Aspects of Rabies  **== <span style="display: block; font-size: 90%; font-family: 'Comic Sans MS', cursive; text-align: left;">The Rabie Virus is a bullet-shaped virus. It’s made of negative stranded genomes. They are approximately 180 nm long and 75 nm wide. A rabie also consist of ribonucleic acids. On the outside of the Rabies, the coat is made of spike shaped glycoprotein peplomers. [|Glycoproteins] are proteins that attach itself to proteins in order to decode them. Which is why they are the spike shape.The Rabi Virus encode five proteins which are [|nucleoprotein] (N), [|phosphoprotein] (P), [|matrix protein] (M),[|glycoprotein] (G) and [|polymerase] (L). When encoding these proteins, the rabies virus are then replicated.



==<span style="font-family: 'Arial Black', Gadget, sans-serif; background-color: rgb(0, 255, 0);"> <span style="background-color: rgb(0, 255, 0); color: rgb(255, 255, 255); font-size: 120%; text-align: center; display: block; font-family: 'Arial Black', Gadget, sans-serif;">Can We Fight It? ==

<span style="font-family: 'Comic Sans MS', cursive; font-size: 90%;">Sadly once rabies are exposed inside of the human body. No cells are able to fight against it. This is because once the rabies are inside the body, it immediately latches onto another cell then immediately multiplying. Once that process is finished, the rabie viruses that were multiplies , move to healthy cells and infect them. The only way humans can fight against being exposed to rabies is if the Vaccine created by Louis Pasture is used within 5 to 10 days prior to the exposure of the virus. When the vaccine is inside of the body before the rabies are in contact with every cell in the body, the vaccine combines with the rabie virus and stops its process of multiplying. <span style="color: rgb(255, 255, 255); background-color: rgb(238, 17, 17); font-size: 90%; text-align: center; display: block;">

<span style="background-color: rgb(139, 199, 249); color: rgb(255, 255, 255); font-size: 130%; font-family: 'Arial Black', Gadget, sans-serif; text-align: center; display: block;">Future of Rabies
<span style="font-family: 'Comic Sans MS', cursive; text-align: left; display: block;"> Rabies have been known in the world for thousands of years. The only mutation scientist have observed within rabies are the infecting subjects.For example at one point rabies were only observed in the mid-eastern part of the globe. But now the virus has immigrated to different parts of the world. However no physical mutation has been observed in the Rabies. It’s weird because a person who’s have never heard of Rabies would suspect that it would’ve mutated over the years. But it hasn’t. The only change that has occurred related to rabies is the vaccine used to treat it. If rabies were to mutate, we believe that the virus would become more deadly. The amount of time it takes for the virus to multiply would possibly be faster than the average Rabbie virus.

**<span style="background-color: rgb(235, 5, 5); font-size: 140%; font-family: 'Arial Black', Gadget, sans-serif; text-align: center; display: block; color: rgb(255, 255, 255);">Treating Rabies **
<span style="font-family: 'Comic Sans MS', cursive; font-size: 90%;">Rabies are treated by a vaccine needle. In the year of 1885 Dr.Louis Paesture created the vaccine. The vaccine is a shot/needle which can be given 5-10 daysprior to the day infected. The vaccine stops the process of the Rabies multiplying within cells. This virus can be prevented by getting a Rabie vaccine before you are bitten/infected by an animal already infected with rabies. The vaccine will protect your cells from being raided by the rabies viruses.

<span style="color: rgb(255, 255, 255); font-size: 20px; font-family: 'Arial Black', Gadget, sans-serif; background-color: rgb(0, 255, 50); text-align: center; display: block;">

<span style="font-family: 'Arial Black', Gadget, sans-serif; background-color: rgb(0, 255, 79); color: rgb(255, 255, 255); font-size: 130%; text-align: center; display: block;">What do Rabies infect?
<span style="font-family: 'Comic Sans MS', cursive; font-size: 90%;">The cells that rabies most infect once in the body is the nervous system cells. This infection occurs because when Rabies are spreading through the saliva of an infected animal. Other animals along with people can get infected if they are bitten or scratched by an infected animals. Once bitten the disease attacks the cells of the nervous system. It then inflames it and cause the salivary glands to inflame and overreact, which makes you foam out the mouth. The organelles involved in this process are <span style="font-family: 'Comic Sans MS', cursive; font-size: 90%;">the cell membrane, then envelopment by phagocytosis or endocytosis. Various protein, glycoprotein and nucleic acid components are also involved. The host cell enzymes that are involved when Rabies are exposed in the human body are Lysosomal enzymes, the DNA repair enzyme, poly ADP-ribose polymerase.

<span style="color: rgb(255, 255, 255); background-color: rgb(0, 140, 255); text-align: center; display: block; font-family: 'Arial Black', Gadget, sans-serif; font-size: 130%;">References
<span style="font-family: 'Comic Sans MS', cursive;"> [] <span style="font-family: 'Comic Sans MS', cursive;"> <span style="font-family: 'Comic Sans MS', cursive;"> [] <span style="font-family: 'Comic Sans MS', cursive;"> []  <span style="font-family: 'Comic Sans MS', cursive;"> <span style="font-family: 'Comic Sans MS', cursive;"> []   <span style="font-family: 'Comic Sans MS', cursive;"> <span style="font-family: 'Comic Sans MS', cursive;"> [|http://www.cnn.com/2009/HEALTH/03/12/angola.rabies/index.html]